A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01)
Patent
CA 2477222
The invention provides a preservative-free midazolam hydrochloride formulation that is less toxic, and more effective than present opioid therapies for alleviation of pain. Additionally, by an intrathecal infusion system for continuous administration of preservative-free midazolam hydrochloride the present invention circumvents breakthrough pain episodes often encountered with other means of opioid administration. The present invention further provides a novel method of treating pain that is of either non-neuropathic or neuropathic origin. Overall that present invention provides a method of treating cancer pain in patients by continuous intrathecal infusion of preservative-free midazolam hydrochloride.
L'invention concerne une préparation de chlorhydrate de midazolam sans agent de conservation, qui est moins toxique et plus efficace que les traitements opioïdes actuels destinés à soulager la douleur. De plus, grâce à un système intrathécal d'administration continue du chlorhydrate de midazolam sans agent de conservation, la méthode de l'invention permet d'éviter des épisodes de douleur perçante souvent rencontrés avec d'autres moyens d'administration d'opioïdes. L'invention concerne également une nouvelle méthode de traitement de la douleur d'origine neurogène ou non neurogène. L'invention concerne en outre une méthode de traitement de la douleur cancéreuse chez des patients, par administration intrathécale continue de chlorhydrate de midazolam sans agent de conservation.
Gradert Tamara L.
Hassenbusch Samuel J.
Johansen Mary Jane
Satterfield William C.
Trissel Larry
Board Of Regents The University Of Texas System
Goudreau Gage Dubuc
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