Aminoaryl sulphonamide derivatives as functional 5-ht6 ligands

Details Aminoaryl sulphonamide derivatives as functional 5-ht6 ligands Aminoaryl sulphonamide derivatives as functional 5-ht6 ligands

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4468 (2006.01) A61K 31/4523 (2006.01)

Patent

CA 2618636

The present invention provides aminoaryl sulphonamide derivatives of formula (I), useful in the treatment of a CNS disorder related to or affected by the 5- HTg receptor. Pharmacological profile of these compounds includes high affinity binding with 5-HTg receptor along with good selectivity towards the said receptor. The present invention also includes the stereoisomers, the salts, methods of preparation and medicine containing the said aminoaryl sulphonamide derivatives.

La présente invention concerne des dérivés de sulphonamides aminoaryles de formule (I) utiles dans le traitement d~un désordre lié au ou affecté par le récepteur 5-HTg. Le profil pharmacologique de ces composés comprend une liaison de haute affinité au récepteur 5-HTg avec une bonne sélectivité envers ledit récepteur. La présente invention comprend aussi les stéréoisomères, les sels, procédés de préparation et médicaments contenant lesdits dérivés de sulphonamides aminoaryles.

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