Piperidine and piperazine derivatives as p2x3 antagonists

Details Piperidine and piperazine derivatives as p2x3 antagonists Piperidine and piperazine derivatives as p2x3 antagonists

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61P 11/00 (2006.01) C07D 213/81 (2006.01) C07D 231/56 (2006.01) C07D 239/42 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2618340

Compounds of formula (I) wherein R1, R2a, R2b, R3, Y, X, A, R6, R7 and R8 are as described herein, are modulators of P2X3 useful for the treatment of pain and genitourinary, gastrointestinal, and respiratory disorders.

La présente invention concerne des composés répondant à la formule (I) dans laquelle R1, R2a, R2b, R3, Y, X, A, R6, R7 et R8 sont tels que décrits dans la description, lesquels sont des modulateurs de P2X3 utiles pour le traitement de la douleur et de troubles génito-urinaires, gastro-intestinaux et respiratoires.

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