Binding members against il-1r1

Details Binding members against il-1r1 Binding members against il-1r1

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2742357

This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-I and IL-1Ra for binding to IL-1R1 and binds I1-1R1 with a KD of 10pM or less when measured by KinexaTM. The binding members are useful for, inter alia, treatment of disorders mediated by IL-1R1 including rheumatoid arthritis, asthma and chronic obstructive pulmonary disease (COPD).

Cette invention porte sur des éléments de liaison, notamment des molécules d'anticorps, spécifiques pour le récepteur 1 de l'interleukine 1 (IL-1R1). L'invention porte, par exemple, sur des éléments de liaison isolés spécifiques pour l'IL-1R1 entrant en compétition avec l'IL-1 et l'IL-1Ra pour la liaison à l'IL-1R1 et se liant à l'IL-1R1 avec une valeur KD de 10pM ou moins, telle que mesurée par KinexaTM. Les éléments de liaison sont utiles, entre autres, pour le traitement de troubles médiés par l'IL-1R1, y compris la polyarthrite rhumatoïde, l'asthme et la bronchopneumopathie chronique obstructive (BPCO).

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