Uses of opg ligand to modulate immune responses

Details Uses of opg ligand to modulate immune responses Uses of opg ligand to modulate immune responses

A - Human Necessities

61

K

A61K 48/00 (2006.01) C07K 14/705 (2006.01) C12N 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2439678

Methods of stimulating or inhibiting activity of monocytes using OPG ligand, or other agonists or antagonists, are provided. Methods of treating pathological conditions, particularly immune related conditions, using such OPG ligand, agonists or antagonists are further provided. Agonists and antagonists contemplated for use in the invention include anti-RANK receptor antibodies, anti-OPG ligand antibodies, anti-OPG receptor antibodies, RANK receptor immunoadhesins, and OPG receptor immunoadhesins.

La présente invention concerne des procédés de stimulation ou d'inhibition de l'activité des monocytes au moyen de ligand, ou autres agonistes ou antagonistes OPG. L'invention concerne également des procédés de traitement de conditions pathologiques, notamment des conditions liées à l'immunité, mettant en oeuvre un tel ligand, agonistes ou antagonistes OPG. Parmi les agonistes et antagonistes utilisés par l'invention se trouvent des anticorps du récepteur anti-RANK, des anticorps de ligands OPG, des anticorps du récepteur anti-OPG, des immunoadhésines du récepteur RANK, et des immunoadhésines du récepteur OPG.

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