Methods for preventing, postponing or improving the outcome...

Details Methods for preventing, postponing or improving the outcome... Methods for preventing, postponing or improving the outcome...

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 45/00 (2006.01) A61L 27/54 (2006.01) A61P 19/04 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2692430

Methods for identifying subjects who could benefit therapeutically from administration of a high specificity cytokine inhibitor are provided. Subjects that are identified include those that are eligible, based on pre-determined criteria, for a spinal device or fusion procedure, such as the implantation of a nucleus replacement device, an annular repair device, or a fusion device. Methods of preventing such procedures or improving the outcome of such procedures are also provided, and include administering a TAT to the subject by any route or regimen of administration, including the regimens described herein.

L'invention concerne des procédés permettant d'identifier des patients qui pourraient bénéficier sur le plan thérapeutique de l'administration d'un inhibiteur de cytokines hautement spécifique. Les patients identifiés comprennent ceux qui sont candidats, sur la base de critères prédéterminés, à un dispositif vertébral ou à une intervention de fusion vertébrale, telle que la mise en place d'un dispositif de remplacement de noyau, d'un dispositif de réparation annulaire ou d'un dispositif de fusion. L'invention concerne également des procédés permettant d'éviter ces types d'interventions ou d'obtenir de meilleurs résultats suite à ces types d'interventions, consistant à administrer au patient un traitement anti-inflammatoire ciblé par n'importe quelle voie d'administration ou selon n'importe quel schéma posologique, y compris les schémas posologiques décrits dans la présente description.

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