Pharmaceutical use of graptopetalum and related plants

Details Pharmaceutical use of graptopetalum and related plants Pharmaceutical use of graptopetalum and related plants

A - Human Necessities

61

K

A61K 36/41 (2006.01) A61P 1/16 (2006.01) A61P 31/20 (2006.01)

Patent

CA 2578877

The present invention relates to compositions comprising Graptopetalum and uses thereof. Graptopetalum can protect animals from liver diseases and medical conditions, such as inflammation, steatosis, and fibrosis. In particular, Graptopetalum inhibits proliferation of activated hepatic stellate cells, which play a pivotal role in liver fibrosis. Graptopetalum also has anti-fibrosis activities as well as inhibits proliferation of lung fibroblasts. Therefore, in addition to being a prophylactic and therapeutic agent for the liver, Graptopetalum is useful against fibrosis or inflammation of tissues or organs other than the liver, in particular lung, kidney, and bladder. Other plants in the family of Crassulaceae, particularly Echeveria, have similar effects as Graptopetalum.

L'invention concerne des compositions comprenant Graptopetalum et des utilisations de celles-ci. Graptopetalum permet de protéger des animaux contre des maladies hépatiques et des états pathologiques tels que l'inflammation, la stéatose et la fibrose. Graptopetalum inhibe en particulier la prolifération de cellules de Kupffer activées, qui jouent un rôle-clé dans la fibrose hépatique. Graptopetalum présente également une activité antifibrose et inhibe la prolifération des fibroblastes pulmonaires. De ce fait, outre ses propriétés prophylactiques et thérapeutiques pour le foie, Graptopetalum est utile contre la fibrose ou l'inflammation de tissus et d'autres organes, notamment le poumon, le rein et la vessie. D'autres plantes de la famille des crassulacées, en particulier Echeveria, ont des effets similaires à ceux de Graptopetalum.

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