Treatment of diseases associated with altered level of...

Details Treatment of diseases associated with altered level of... Treatment of diseases associated with altered level of...

C - Chemistry, Metallurgy

07

D

C07D 279/02 (2006.01) A61K 31/541 (2006.01) A61P 21/00 (2006.01)

Patent

CA 2567223

A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid ~ peptides (A~) and/or with a changed ratio of levels of A isoforms and/or with the formation of plaques containing amyloid ~ peptide (A~) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas (Ia), (Ib) wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.

Un procédé de traitement et de prévention d'une maladie ou d'un état associé à un niveau plus élevé d'isoformes de peptides ß-amyloïdes (Aß) et/ou avec un rapport modifié de niveaux d'isoformes A et/ou avec la formation de plaques contenant des isoformes de peptides ß-amyloïdes (Aß) chez un mammalien consiste à administrer audit mammalien une quantité thérapeutiquement efficace d'un composé sélectionné parmi les formules (Ia), (Ib) dans lesquelles V, W, Y, R2, R3, R5, R6, L1 et i sont définies dans la revendication 1.

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