Novel lactam inhibitors of matrix metalloproteinases,...

Details Novel lactam inhibitors of matrix metalloproteinases,... Novel lactam inhibitors of matrix metalloproteinases,...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/47 (2006.01) A61P 29/00 (2006.01) C07D 207/26 (2006.01)

Patent

CA 2361848

The present application describes novel lactams and derivatives thereof of formula (I) or pharmaceutically acceptable salt forms thereof, wherein ring B is a 4-8 membered lactam containing from 0-3 additional heteroatoms selected from N, O, and S, which are useful as inhibitors of matrix metalloproteinases, TNF-.alpha., and aggrecanase.

La présente invention concerne de nouveaux lactames et des dérivés de ceux-ci de formule (I), ou des formes salines pharmaceutiquement acceptables de ceux-ci, le cycle B représentant un lactame avec 4 à 8 chaînons qui contient de 0 à 3 hétéroatomes supplémentaires choisis parmi N, O, et S, ces nouveaux lactames et leurs dérivés pouvant être utilisés comme inhibiteurs de métalloprotéases matricielles, de TNF-alpha, et de l'aggrécanase.

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