Treatment of emphysema using rar selective retinoid antagonists

Details Treatment of emphysema using rar selective retinoid antagonists Treatment of emphysema using rar selective retinoid antagonists

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/192 (2006.01) A61K 31/352 (2006.01) A61K 31/353 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2387844

This invention provides the use of RAR.gamma. selective agonists for the manufacture of a medicament containing one or more such agonists for the treatment of emphysema and other diseases associated with alveolar damage. In another aspect, this invention provides the use of RAR agonists, preferably a RAR.gamma. selective agonist for the manufacture of medicaments for promoting tropoelastin gene expression and alveolar matrix repair.

L'invention concerne l'utilisation d'agonistes sélectifs pour RAR gamma afin de préparer un médicament contenant un ou plusieurs de ces agonistes pour traiter l'emphysème et d'autres maladies associées à une détérioration alvéolaire. Dans un autre aspect, l'invention concerne l'utilisation d'agonistes de RAR (récepteur d'acide rétinoïque), de préférence un agoniste sélectif pour RAR gamma afin de préparer des médicaments servant à promouvoir l'expression du gène de tropoélastine, ainsi que la réparation de la matrice alvéolaire.

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