Integrin antagonists

Details Integrin antagonists Integrin antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/4375 (2006.01) A61K 31/444 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/506 (2006.01) C07D 471/04 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2263999

This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are .alpha.v.beta.3 antagonists, .alpha.v.beta.5 antagonists or dual .alpha.v.beta.3/.alpha.v.beta.5 antagonists useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation and tumor growth.

L'invention porte sur certains composés nouveaux et leurs dérivés, leur synthèse et leur utilisation en tant qu'antagonistes du récepteur de la vitronectine. Lesdits composés antagonistes du récepteur de la vitronectine sont des antagonistes .alpha.v.beta.3, des antagonistes .alpha.v.beta.5 ou des antagonistes doubles .alpha.v.beta.3/.alpha.v.beta.5, qui servent à inhiber la résorption osseuse, prévenir et traiter l'ostéoporose et inhiber la resténose, la rétinopathie diabétique, la dégénérescence maculaire, l'angiogénèse, l'athérosclérose, l'inflammation et la croissance de tumeurs.

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