Gtpase inhibitors and methods of use

Details Gtpase inhibitors and methods of use Gtpase inhibitors and methods of use

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2546727

The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.

Les modes de réalisation préférés de cette invention concerne des procédés et des compositions modifiant l'activité de liaison GTP des éléments GTPases de la famille Rho, de préférence Rac (Rac1, Rac2 et/ou Rac3), ces compositions contiennent des composés qui modulent l'activité d'échange GTP/GDP, avec l'utilisation pour les composés impliquant le criblage de composé qui reconnaissent le GTPase Rac, et des procédés de traitement de troubles pathologiques associés ou relatifs à la GTPase de la famille Rho, ainsi que Rac. Les modes de réalisation préférés de cette invention concerne aussi des procédés d'utilisation de ces composés, ou de dérivés de ceux-ci, notamment dans le traitement, le diagnostic, et en tant qu'outils de recherche.

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