Anticancer treatment with a combination of taxanes and...

Details Anticancer treatment with a combination of taxanes and... Anticancer treatment with a combination of taxanes and...

A - Human Necessities

61

K

A61K 31/704 (2006.01) A61K 31/337 (2006.01) A61K 31/65 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2649753

A 13-deoxy anthracycline and a taxane can be administered to a patient simultaneously, separately, sequentially, or consecutively to produce a therapeutic anticancer effect with reduced toxicity and side effect profile, compared to the administration of equieffectrve amounts of either compound alone. A composition or preparation of a 13-deoxy anthracyclines and a taxane for producing a potent anticancer therapeutic effect is also provided.

Une 13-désoxyanthracycline et un taxane peuvent être administrés à un patient simultanément, séparément, de façon séquentielle ou de façon consécutive pour produire un effet thérapeutique anticancéreux de toxicité et de profil d'effets secondaires réduits par comparaison à l'administration de quantités équiactives de l'un ou l'autre des composés seuls. La présente invention concerne en outre une composition ou une préparation d'une 13-désoxyanthracycline et d'un taxane destinée à produire un puissant effet thérapeutique anticancéreux. Figure 1 Effects of Paclitaxel and Anthracycline IC30 Treatment on MCF7 Human Mammary Tumor Cell Growth Effet d'un traitement par le paclitaxel et l'anthracycline IC30 sur la croissance de cellules tumorales mammaires humaines MCF7 paclitaxel paclitaxel paclitaxel+doxorubicin (I) paclitaxel+doxorubicine (I) paclitaxel+cmpd II paclitaxel+comp. II paclitaxel+cmpd III paclitaxel+comp. III Percent of Control Pourcentage de référence Concentration of Paclitaxel nM Concentration en paclitaxel en nM

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