Novel bioluminescent assays and bacterial strains useful...

Details Novel bioluminescent assays and bacterial strains useful... Novel bioluminescent assays and bacterial strains useful...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/02 (2006.01) G01N 33/533 (2006.01) G01N 33/567 (2006.01) G01N 33/569 (2006.01) G01N 33/573 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2365791

The present invention relates to novel assays for assessing the degree to which a cell is metabolically active. Also provided, are mutagenicity assays and, more specifically, methods for determining whether a given agent is genotoxic. Embodiments of the assays employ a microorganism, or a mammalian cell, that has been genetically modified to produce light when the presence of test agent results in a mutation, e.g., reversion or forward, in the DNA of such microorganism or cell.

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