Pharmaceutical compositions directed to erb-b1 receptors

Details Pharmaceutical compositions directed to erb-b1 receptors Pharmaceutical compositions directed to erb-b1 receptors

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01)

Patent

CA 2501818

The invention relates to pharmaceutical compositions comprising different molecules, preferably monoclonal antibodies, each comprising epitopes that bind simultaneously to different sites within the same ErbB 1 receptor domain. The preferred antibodies according to this invention are MAb 425 and MAb 225 each in its murine, chimeric and humanized version. The invention relates to the use and methods for an improved treatment of preferably tumors by means of said compositions.

Cette invention a trait à des compositions pharmaceutiques renfermant différentes molécules, de préférence des anticorps monoclonaux, chacun de ceux-ci renfermant des épitopes se liant simultanément à différentes sites du même domaine du récepteur ERB-1. Les anticorps préférés de l'invention sont MAb 425 et MAb 225, chacun dans sa version murine, chimère et humanisée. L'invention concerne également leur utilisation ainsi que des méthodes permettant d'améliorer le traitement de tumeurs, de préférence, à l'aide de ces compositions.

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