C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 48/00 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2754749
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Sirtuin 1 (SIRT1), in particular, by targeting natural antisense polynucleotides of Sirtuin 1 (SIRT1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of SIRT 1.
La présente invention porte sur des oligonucléotides antisens qui modulent l'expression et/ou la fonction de Sirtuine 1 (SIRT1), en particulier par ciblage de polynucléotides antisens naturels de Sirtuine 1 (SIRT1). L'invention porte également sur l'identification de ces oligonucléotides antisens et sur leur utilisation dans le traitement de maladies et de troubles associés à l'expression de SIRT 1.
Coito Carlos
Collard Joseph
de Leon Belinda
Khorkova Sherman Olga
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Opko Curna Llc
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