Recombinant narbonolide polyketide synthase

Details Recombinant narbonolide polyketide synthase Recombinant narbonolide polyketide synthase

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) C12N 1/21 (2006.01) C12N 9/00 (2006.01) C12N 9/14 (2006.01) C12N 15/65 (2006.01) C12N 15/76 (2006.01)

Patent

CA 2328427

Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.

L'invention porte sur des composés d'ADN de recombinaison qui codent tout ou partie de la synthase de polyketide narbonolide et qui sont utilisés pour exprimer des gènes de la synthase de polyketides de recombinaison dans des cellules hôtes pour la production de narbonolide et de dérivés de narbonolide, et de polyketides qui sont utiles comme antibiotiques et comme intermédiaires dans la synthèse de composés ayant une valeur pharmaceutique.

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