Benzisothiazolinone-1-dioxide derivatives as elastase...

Details Benzisothiazolinone-1-dioxide derivatives as elastase... Benzisothiazolinone-1-dioxide derivatives as elastase...

A - Human Necessities

61

K

167/234, 167/310

A61K 31/425 (2006.01) C07D 275/06 (2006.01) A61K 7/48 (1990.01)

Patent

CA 2037665

ABSTRACT BENZISOTHIAZOLINONE-1-DIOXIDE DERIVATIVES AS ELASTASE INHIBITORS The invention relates to pharmaceutical and cosmetic compositions comprising at least one benzisothiazolinone-1- dioxide derivative with the formula: Image (1) where R1 can be hydrogen, and R2 can be certain generally hydrophobic C8-C20 aliphatic groups or the group: Image (III) where R5 is aliphatic or else R2 is a saturated or unsaturated C2-C6 group ending in an aromatic nucleus. These compositions can be used to inhibit elastases such as human leucocytic elastase. They may be applied topically as a cosmetic. Many of the benzisothiazolinone-1-dioxide derivative specified as active ingredient in such compositions are novel compounds.

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