Method of prognosis of mental diseases, e. g. autism and...

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G01N 33/68 (2006.01)

Patent

CA 2598945

The invention provides a method of prognosis for applied behavioural analysis treatment of mental disease, in particular autism or cerebral palsy, in a human subject, said method comprising analyzing a sample of body tissue or fluid from said subject for the presence or absence of a chemical marker indicative of the likelihood of success or failure of applied behavioural analysis treatment of said mental disease, and optionally, based on said analysis, beginning, continuing or ceasing applied behavioural analysis treatment of said subject. The sample is preferably an urine sample, and the preferred prognostic markers are: gluten derivatives, indolyl-3- acryloylglycine (IAG) , serotonin uptake stimulator, .beta.- casomorphineamides, gliadinomorphine, .beta.-casomorphines, deltorphins, Demorphine, glutemorphine , gluten exophins, compounds of molecular weight of 687 Daltons.

L~invention concerne un procédé de pronostic de traitement d~analyse comportementale appliquée d~une maladie mentale, en particulier l~autisme ou la paralysie par encéphalopathie, chez un sujet humain, ledit procédé consistant à analyser un échantillon de tissu corporel ou de fluide corporel provenant dudit sujet pour rechercher la présence ou l~absence d~un marqueur chimique indicatif de la probabilité de réussite ou d~échec du traitement d~analyse comportementale appliquée de ladite maladie mentale, et éventuellement, sur la base de ladite analyse, commencer, poursuivre ou cesser le traitement d~analyse comportementale appliquée dudit sujet. L~échantillon est de préférence un échantillon d~urine, et les marqueurs de pronostic préférés sont : les dérivés de gluten, l~indolyl-3-acryloylglycine (IAG) , le stimulateur de prise de sérotonine, les .beta.-casomorphineamides, la gliadinomorphine, les .beta.-casomorphines, les deltorphines, la démorphine, la glutémorphine , les exophines de gluten, les composés de poids moléculaire de 687 Daltons.

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