Antimicrobial reservoirs for implantable medical devices

Details Antimicrobial reservoirs for implantable medical devices Antimicrobial reservoirs for implantable medical devices

A - Human Necessities

61

L

A61L 27/54 (2006.01) A61L 27/16 (2006.01) A61L 29/16 (2006.01) A61L 31/16 (2006.01) A61F 2/24 (2006.01)

Patent

CA 2412492

Implantable antimicrobial medical devices comprise one or more antimicrobial reservoirs, each such reservoir comprising one or more porous, hydrophobic cores which incorporate antimicrobial substances in predetermined distributions for timed release in vivo. Predetermined distributions of antimicrobial substances incorporated in antimicrobial reservoir cores are achieved through use of supercritical fluid solvent carriers. Precipitation of antimicrobial substances from such solvent carriers in predetermined distributions is accomplished through application of heating, cooling or decreased ambient pressure to the solvent carriers.

L'invention concerne des dispositifs médicaux antimicrobiens implantables comprenant un ou plusieurs noyaux hydrophobes, poreux contenant des substances antimicrobiennes dans des distributions prédéfinies pour une libération lente in vivo. Ces distributions prédéfinies de substances antimicrobiennes introduites dans des noyaux de réservoir antimicrobien sont effectuées par utilisation de supports de solvant fluide supercritique. La précipitation de substances antimicrobiennes de tels supports de solvant dans des distributions prédéfinies est accomplie par chauffage, refroidissement ou application de pression ambiante diminuée aux supports de solvant.

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