Dsp-9 dual-specificity map kinase phosphatase

Details Dsp-9 dual-specificity map kinase phosphatase Dsp-9 dual-specificity map kinase phosphatase

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12N 15/11 (2006.01) C12Q 1/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2367403

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-9, and polypeptide variants thereof that stimulate dephosphorylation of DSP-9 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-9 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

L'invention concerne des compositions et des méthodes pour le traitement de maladies associées à la prolifération cellulaire, la différenciation cellulaire et/ou la survie cellulaire. L'invention concerne notamment la phosphatase à double spécificité DSP-9 ainsi que ses variantes polypeptidiques qui stimulent la déphosphorylation des substrats de DSP-9. Les polypeptides peuvent servir, par exemple, à identifier des anticorps et d'autres agents qui inhibent l'activité de DSP-9. Ces polypeptides et ces agents peuvent servir à moduler la prolifération cellulaire, la différenciation cellulaire et la survie cellulaire.

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