Using multiple perturbations to elucidate connectivity in...

G - Physics – 06 – F

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G06F 13/00 (2006.01)

Patent

CA 2540007

One embodiment of the invention is a method of analyzing the effects of combined perturbers of a network system by means of a set of model predictions for various network configurations, using a set of phenomenologically-based combination surface models. This method can be used to predict the effects of combined perturbers of known networks, for example, providing mechanistic validation for therapeutic compounds. Alternatively, this method can provide constraints for constructing connectivity models from observed combination effects on networks of unknown structure, thus, for example, providing the required understanding to identify novel targets for therapeutic compounds.

Dans un mode de réalisation, cette invention concerne un procédé pour analyser les effets de perturbateurs combinés d'un système de réseau, au moyen d'un ensemble de prédictions modèles pour diverses configurations de réseau, un ensemble de modèles superficiels de combinaison fondés sur la phénoménologie étant utilisés. Ce procédé peut servir à prédire les effets de perturbateurs combinés de réseaux connus, par exemple pour valider de manière mécaniste des composés thérapeutiques. Autre possibilité, ledit procédé peut fournir des contraintes pour construire des modèles de connectivité à partir d'effets de combinaison observés sur des réseaux de structure inconnue, et ainsi par exemple fournir la compréhension requise pour identifier de nouvelles cibles pour des composés thérapeutiques.

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