Thienopyrimidine derivatives, their production and use

Details Thienopyrimidine derivatives, their production and use Thienopyrimidine derivatives, their production and use

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2130859

Abstract of The Disclosure A thienopyrimidie derivative of the formula: Image wherein each of R1 and R2 is hydrogen or an optionally- substituted hydrocarbon residue; R3 is hydrogen or a group which is bonded through a carbon atom or nitrogen atom; R4 is an optionally-substituted hydrocarbon residue; W is a chemical bond or a connecting group and n is an integer of 1-3, or a salt thereof has potent endothelin antagonist activity, thus being used for treating or preventing acute renal insufficiency, myocardial infarction, liver insufficiency, angina pectoris, cerebral infarction, sub-arachnoid haemorrhage (SAH), hypertension, renal insufficiency, asthma, variant form of angina, Raynaud's syndrome, pulmonary hypertension, surgery shock, chronic cardiac insufficiency, cardiac hypertrophy, arteriosclerosis, migraine and the like, furthermore, for treating or preventing a hypofunction of an organ (e.g. liver, etc.) caused by its surgery or transplant, insufficient microcirculation, still fruthermore, for preventing restenosis after PTCA.

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