C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/07 (2010.01) A61F 2/02 (2006.01) A61L 27/20 (2006.01) A61L 27/22 (2006.01) A61L 27/38 (2006.01) B29C 47/00 (2006.01) C08L 89/06 (2006.01) C12N 11/02 (2006.01) C07K 14/78 (2006.01) C08H 1/06 (2006.01)
Patent
CA 2528134
A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed. Methods for using the artificial tissue are also disclosed.
L'invention concerne un support tissulaire tubulaire lequel comprend un tube présentant une paroi, la paroi comprenant des fibrilles biopolymères qui sont alignées en une configuration hélicoïdale autour de l'axe longitudinal du tube, le pas de la configuration hélicoïdale changeant avec la position radiale dans la paroi du tube. Le support est capable de diriger la configuration morphologique de cellules fixées et en croissance pour former une configuration hélicoïdale autour des parois du tube. De plus, l'invention concerne un appareil de production d'un tel support tissulaire tubulaire, l'appareil comprenant une pompe d'alimentation en une dispersion de gel biopolymère qui est reliée fonctionnellement à un dispositif formant le tube ayant un orifice de sortie, le dispositif formant le tube étant capable de produire un tube à partir de la dispersion en gel tout en permettant une force de cisaillement angulaire dans la paroi du tube, et un bain de liquide placé pour recevoir le support de tissu tubulaire du dispositif de formation du tube. L'invention concerne également un procédé de production des supports tissulaires tubulaires. L'invention concerne aussi du tissu artificiel comprenant des cellules vivantes fixées à un support tissulaire tubulaire et des procédés d'utilisation du tissu artificiel.
Goldsmith Edie C.
Goodwin Richard L.
Gore Michael C.
Terracio Louis
Yost Michael J.
Mcfadden Fincham
University Of South Carolina
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