Blockade of t lymphocyte down-regulation associated with...

Details Blockade of t lymphocyte down-regulation associated with... Blockade of t lymphocyte down-regulation associated with...

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 14/31 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2239448

T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.

L'activation de lymphocytes T en réponse à un antigène est accrue par l'administration d'agents de liaison qui bloquent la signalisation par CTLA-4. Lorsque la signalisation par CTLA-4 est ainsi bloquée, la réponse des lymphocytes T à l'antigène est libérée de toute inhibition. Une telle réponse améliorée est utile pour traiter les tumeurs et les infections virales chroniques et comme adjuvant lors d'une immunisation.

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