Retinal pigment epithelial stem cells

Details Retinal pigment epithelial stem cells Retinal pigment epithelial stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/074 (2010.01) C12N 5/071 (2010.01) C12N 5/079 (2010.01) A61K 35/30 (2006.01) A61P 25/00 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2721952

The present invention relates to a retinal pigment epithelial stem cell isolated from a posterior region of the retinal pigment epithelium of an adult mammal. The invention also relates to a method of inducing differentiation of retinal epithelial stem and progenitor cells in vitro, wherein the cells of the invention are highly plastic, multipotential stem cells. The invention also includes methods for the treatment of retinal diseases and vision loss involving the transplantation of retinal pigment epithe-lial stem cells or cells differentiated from retinal pigment epithelial stem cells to the retina of a patient in need of treatment.

Cette invention concerne une cellule souche de l'épithélium pigmentaire rétinien isolée d'une région postérieure de l'épithélium pigmentaire rétinien d'un mammifère adulte. Elle concerne également un procédé pour induire la différenciation des cellules souches et progéniteurs de l'épithélium pigmentaire rétinien in vitro, les cellules souches selon l'invention étant des cellules souches multipotentes, très plastiques. L'invention concerne également des procédés pour traiter les maladies rétiniennes et la perte de vision impliquant la greffe de cellules souches de l'épithélium pigmentaire rétinien ou de cellules différenciées des cellules souches de l'épithélium pigmentaire rétinien sur la rétine d'un patient ayant besoin dudit traitement.

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