Pyrimidine derivatives for inhibition of cell-proliferation

Details Pyrimidine derivatives for inhibition of cell-proliferation Pyrimidine derivatives for inhibition of cell-proliferation

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2438646

Compounds of the formula (I): wherein Ring A, R1, R3, R4, p, q, and n are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm- quest-blooded animal, such as man.

L'invention concerne des composés représentés par la formule (I), dans laquelle l'anneau A, R?1¿, R?3¿, R?4¿, p, q, et n sont tels que définis dans le descriptif, ainsi que des sels pharmaceutiquement acceptables et des esters hydrolysables in vivo. L'invention concerne également des procédés de préparation de ceux-ci ainsi que leur utilisation en tant que médicaments, plus spécifiquement des médicaments pour produire un effet inhibiteur du cycle cellulaire (anti-prolifération cellulaire) chez un animal à sang chaud tel que l'homme.

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