Controlled release pharmaceutical composition containing...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/135 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2397942

The invention relates to a controlled release pharmaceutical composition containing as active ingredient tramadol hydrochloride. The pharmaceutical composition according to the invention contains 100 to 200 mg of the active ingredient in admixture with a micronized ester of glycerol with a higher fatty acid, an alkali salt of phosphoric acid, a non-ionic vinylpyrrolidone polymer and a tabletting agent selected from the group consisting of salts of higher fatty-acids with alkaline earth metals and silicon oxides.

L'invention concerne une composition pharmaceutique à libération régulée contenant du chlorhydrate de tramadol. Cette composition se caractérise en ce qu'elle contient entre 100 et 200 mg d'ingrédient actif mélangé à des esters micronisés de glycérol avec des acides gras, des sels alcalins d'acide phosphorique, des polymères de vinylpyrrolidone non ioniques, des substances issues du groupe constitué par des sels d'acides gras supérieurs avec des métaux alcalino-terreux et des oxydes de silicium. L'invention concerne également un procédé de préparation de cette composition.

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