Phenylpyridine carbonyl piperazine derivative

Details Phenylpyridine carbonyl piperazine derivative Phenylpyridine carbonyl piperazine derivative

C - Chemistry, Metallurgy

07

D

C07D 213/81 (2006.01) A61K 31/439 (2006.01) A61K 31/4418 (2006.01) A61K 31/4427 (2006.01) A61K 31/443 (2006.01) A61K 31/4433 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/5355 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/

Patent

CA 2448298

A compound represented by the following general formula, which has phosphodiesterase IV inhibitory activity; a use of the compound; and an intermediate therefor. (I) (In the formula, R1 and R2 each is hydrogen, halogeno, lower alkyl, lower alkoxy, etc.; R3 and R4 each is hydrogen, (substituted) lower alkyl, halogeno, etc.; R5 is hydrogen, lower alkyl, lower alkoxycarbonyl, etc.; and n is 0 or 1.)

La présente invention concerne un composé de formule générale (I), dans laquelle R1 et R2 représentent chacun hydrogène, halogéno, alkyle inférieur, alcoxy inférieur; R3 et R4 représentent chacun hydrogène, alkyle inférieur (substitué), halogéno; R5 représente hydrogène, alkyle inférieur, alcoxycarbonyl inférieur ; n est 0 ou 1. Ledit composé présente une activité d'inhibition de la phosphodiestérase IV. L'invention concerne également l'utilisation dudit composé, et un intermédiaire.

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