C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2725755
The invention relates to substituted pyrrole compounds of Formula (I) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1(chkl) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
L'invention porte sur des composés pyrroles substitués de Formule (I) qui sont utiles en tant qu'inhibiteurs de kinases, plus spécifiquement utiles en tant qu'inhibiteurs de la checkpoint kinase 1 (chkl), étant de ce fait utiles en tant que produits thérapeutiques contre le cancer. L'invention porte également sur des compositions, plus spécifiquement sur des compositions pharmaceutiques comprenant ces composés, et sur des procédés d'utilisation de celles-ci pour traiter diverses formes de cancer et des troubles hyperprolifératifs, ainsi que sur des procédés d'utilisation des composés pour un diagnostic ou un traitement in vitro, in situ et in vivo de cellules de mammifère ou d'états pathologiques associés.
Gazzard Lewis J.
Lyssikatos Joseph P.
Genetech Inc.
Smart & Biggar
LandOfFree
Substituted pyrroles and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted pyrroles and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted pyrroles and methods of use will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2050559