A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/19 (2006.01) A61P 1/16 (2006.01)
Patent
CA 2507008
CC-chemokine mutants having reduced Glycosaminoglycans (GAG)-binding properties are effective against liver fibrotic inflammatory and/or autoimmune diseases. Particularly preferred are the mutants of CCL5/RANTES having reduced GAG-binding properties.
La présente invention a trait à des mutants de la CC-chimiokine présentant des propriétés réduites de liaison aux glycosaminoglycanes (GAG) efficaces contre les maladies inflammatoires fibreuses et/ou auto-immunes du foie. Les mutants particulièrement préférés sont les CCL5/RANTES présentant des propriétés réduites de liaison
Ajuebor Maureen
Proudfoot Amanda
Swain Mark
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
Laboratoires Serono S.a.
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