A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2737399
The present invention relates to inhalable particles comprising a stabilized amorphous form of tiotropium with a stabilizing agent. It also relates to inhalable particles comprising a stabilized amorphous form of tiotropium with a stabilizing agent mixed with one or more coarse excipients having a mean particle size of 15 to 250 µm. It also relates to a pharmaceutical composition comprising the inhalable particles of the invention, to a process for their preparation, and to their use for the preparation of a medicament for the treatment of asthma or chronic obstructive pulmonary disease (COPD).
La présente invention porte sur des particules inhalables contenant une forme amorphe stabilisée de tiotropium avec un agent stabilisant. Linvention concerne également des particules inhalables contenant une forme amorphe stabilisée de tiotropium avec un agent stabilisant, mélangée à un ou plusieurs gros excipients dune taille particulaire moyenne comprise entre 15 et 250 µm. Linvention porte en outre sur une composition pharmaceutique contenant les particules inhalables de linvention, sur un procédé de préparation correspondant, ainsi que sur lutilisation de ces particules dans la préparation dun médicament destiné au traitement de lasthme ou de la broncho-pneumopathie chronique obstructive (BPCO).
Amighi Karim
Sereno Guerra Antonio
Laboratorios Liconsa S.a.
Robic
LandOfFree
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