Pharmaceutical composition containing cefuroxime axetil...

Details Pharmaceutical composition containing cefuroxime axetil... Pharmaceutical composition containing cefuroxime axetil...

A - Human Necessities

61

K

A61K 31/546 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 31/545 (2006.01)

Patent

CA 2322432

The present invention relates to a pharmaceutical composition containing cefuroxine axetil wherein the active ingredient is not gelled by moisture absorption and is thus stable during storage period. More specifically, the present invention relates to a pharmaceutical composition which comprises amorphous cefuroxime axetil as an active ingredient and silicon dioxide or its hydrate as a micro-environmental pH adjustor and an anti-gelling agent for cefuroxime axetil. The composition according to the present invention can be provided in the oral formulation such as tablets, capsules, granules, powders and dry syrups.

Composition pharmaceutique contenant du cefuroxime axetil, le principe actif n'étant pas gélifié par absorption d'humidité et étant donc stable pendant la période de stockage. Plus spécifiquement, la présente invention concerne une composition pharmaceutique qui comporte du cefuroxime axetil amorphe en tant que principe actif et du dioxyde de silicium ou son hydrate en tant que correcteur de pH micro-environnemental, ainsi qu'un agent anti-gélifiant pour le cefuroxime axetil. La composition selon la présente invention peut se présenter sous forme posologique orale telle que des comprimés, des capsules, des granules, des poudres et des sirops secs.

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