Tumor specific monoclonal antibodies

Details Tumor specific monoclonal antibodies Tumor specific monoclonal antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) C07K 16/32 (2006.01)

Patent

CA 2467020

The invention provides tumor-specific human monoclonal antibodies and functional fragments. Also provided are nucleic acids encoding tumor-specific human monoclonal antibodies and functional fragments. A method for reducing neoplastic cell proliferation is also provided. The method consists of administering an effective amount of a tumor-specific human monoclonal antibody or functional fragment. Also provided is a method of detecting a neoplastic cell in a sample. The method consists of contacting a cell with a tumor-specific monoclonal antibody or functional fragment and detecting the specific binding of the human monoclonal antibody or functional fragment to the sample.

L'invention concerne des anticorps monoclonaux spécifiques de tumeur et des fragments fonctionnels ; des acides nucléiques codant pour des anticorps monoclonaux humains spécifiques de tumeur et des fragments fonctionnels ; un traitement visant à réduire la prolifération de cellules néoplasiques. Le traitement consiste à administrer une quantité efficace d'un anticorps monoclonal humain spécifique de tumeur ou d'un fragment fonctionnel. L'invention concerne également un procédé de détection d'une cellule néoplasique dans un échantillon. Ce procédé consiste à mettre en contact une cellule avec un anticorps monoclonal spécifique de tumeur ou un fragment fonctionnel, et à détecter la liaison spécifique de cet anticorps ou du fragment fonctionnel avec l'échantillon.

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