Triazolopurine derivative, pharmaceutical composition...

Details Triazolopurine derivative, pharmaceutical composition... Triazolopurine derivative, pharmaceutical composition...

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/505 (2006.01) A61K 31/675 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2326716

Disclosed is a triazolopurine derivative represented by the general formula: (see formula 1) wherein R1 and R2 represent the same groups as those described in the specification; and A represents a group: (see formula 2, 3 or 4) wherein R3 represents the same groups as those described in the specification. This compound is incorporated in a pharmaceutical composition because of its affinity to an adenosine A3 receptor, and is used as an adenosine A3 receptor antagonist or a remedy for asthma.

L'invention concerne des dérivés de triazolopurine représentés par la formule (1). Dans cette formule, R<1> et R<2> sont chacun définis dans le descriptif; A représente un groupe représenté par (a), (b) ou (c) (où R<3> est tel que défini dans le descriptif). Ces composés présentent une affinité pour un récepteur de l'adénosine A3. Une composition médicinale contenant n'importe lequel de ces composés est utilisée comme agent de compatibilisation de récepteur de l'adénosine A3 ou comme médicament contre l'asthme.

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