C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01)
Patent
CA 2213846
This invention provides a novel gene, OVCA1, isolated from human chromosome 17p13.3. Disruption of the OVCA1 gene is associated with cellular proliferation and tumor development. The OVCA1 gene, along with its encoded protein and antibodies thereto, provides a biological marker for early diagnosis of metastatic disease. The gene also will be useful in gene replacement therapy for treating various forms of cancer.
La présente invention décrit un gène nouveau, OVCA1, isolé à partir du chromosome humain 17p13.3. La disruption du gène OVCA1 est associée à la prolifération cellulaire et au développement de tumeurs. Ledit gène OVCA1, ainsi que la protéine qu'il code et les anticorps dirigés contre celle-ci, fournit un marqueur biologique permettant le diagnostic précoce d'une maladie métastatique. Ledit gène sera également utile dans une thérapie génique supplétive pour traiter diverses formes de cancer.
Borden Ladner Gervais Llp
Fox Chase Cancer Center
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