Therapeutically useful tetracyclic ligands

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 498/16 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61P 25/22 (2006.01) C07D 513/16 (2006.01)

Patent

CA 2453219

The present invention provides compounds of Formula (I): INSERT CHEMICAL FORMULA HERE, wherein R1, R2, R3, R4, R5, R6, R7, and R8 have any of the values defined in the specification, as well as pharmaceutical compositions comprising the compounds. The invention also provides therapeutic methods as well as processes and intermediates useful for preparing compounds of Formula (I). The compounds are 5-HT ligands, and are useful for treating diseases whereas modulation of 5-HT activity is desired.

L'invention concerne des composés de formule (I): (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿ et R?8¿ ont une quelconque des valeurs définies dans les spécifications, ainsi que des préparations pharmaceutiques contenant ces composés. La présente invention porte également sur des méthodes thérapeutiques, des procédés et des produits intermédiaires utiles pour préparer les composés de la formule (I). Ces composés, qui sont des ligands 5-HT, s'avèrent utiles pour le traitement de maladies où l'activité 5-HT doit être modulée.

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