Human chemokine polypeptides

Details Human chemokine polypeptides Human chemokine polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01)

Patent

CA 2198219

Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

Polypeptides de type chémokine humaine, ADN (ARN) codant lesdits polypeptides et procédé de production desdits polypeptides par des techniques de recombinaison. Des procédés d'utilisation desdits polypeptides dans le traitement de la leucémie, des tumeurs, des infections chroniques, des maladies auto-immunes, des fibroses, de la cicatrisation et du psoriasis sont également décrits, ainsi que des antagonistes desdits polypeptides et leur utilisation en tant qu'agents thérapeutiques pour traiter la polyarthrite chronique évolutive, les inflammations auto-immunes et chroniques et les maladies infectieuses, les réactions allergiques, la fièvre indépendante des prostaglandines et l'insuffisance médullaire.

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