Platelet specific immunoconjugates

Details Platelet specific immunoconjugates Platelet specific immunoconjugates

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2051436

2051436 9011783 PCTABS00002 Immunoconjugates are described comprising a platelet-specific antibody or antibody fragment coupled to a thrombolytic agent. The antibody, or fragment thereof, is, preferably, specific for the glycoprotein IIb/IIIa receptor in its complexed form. These antibodies block ligand binding to the receptor, thereby preventing platelet aggregation which has been implicated in the formation of thrombi. The thrombolytic agent, either in natural or recombinant form, promotes fibrinolysis in the thrombus. These immunoconjugates are useful in anti-thrombotic therapy.

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