Chiral cis-imidazolines

Details Chiral cis-imidazolines Chiral cis-imidazolines

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/454 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2701932

There are provided compounds of Formula (I), or the pharmaceutically acceptable salts thereof, wherein X, Y, Z, V1, V2, R1, R2, R3, R4 and R5 are as herein described, processes for obtaining said compounds and pharmaceutical preparations containing them. These compounds are useful as anticancer agents, in particular as agents in the treatment of solid tumors.

L'invention porte sur des composés représentés par la Formule (I), ou sur leurs sels pharmaceutiquement acceptables, formule dans laquelle X, Y, Z, V1, V2, R1, R2, R3, R4 et R5 sont tels que présentement décrits, sur des procédés d'obtention desdits composés, et sur des préparations pharmaceutiques les contenant. Ces composés sont utiles comme agents anti-cancer, en particulier comme agents dans le traitement de tumeurs solides.

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