Pyrazoles and methods of making and using the same

Details Pyrazoles and methods of making and using the same Pyrazoles and methods of making and using the same

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2514382

The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).

L'invention concerne des composés de formule (I) présentant une affinité étonnamment élevée pour Alk 5 et/ou Alk 4, et pouvant être utiles en tant qu'antagonistes de ceux-ci, pour prévenir et/ou pour traiter un grand nombre de maladies, notamment des troubles fibrotiques. Dans un mode de réalisation, l'invention concerne un composé de formule (I).

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