A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/165 (2006.01) A61P 35/04 (2006.01)
Patent
CA 2662140
The invention provides methods of inhibiting angiogenesis in an individual by administering a composition (such as protein containing composition) comprising colchicine or thiocolchicine dimer. The composition is in an amount that is effective in inhibiting angiogenesis but is in some embodiments insufficient to induce significant cytotoxicity in the individual. The methods described herein are useful for treating angiogenesis-associated diseases, such as age-related macula degeneration, diabetic retinopathy, rheumatic arthritis, psoriasis, and cancer.
La présente invention concerne des procédés d'inhibition de l'angiogenèse chez un individu par l'administration d'une composition (telle qu'une composition contenant une protéine) comprenant de la colchicine ou un dimère de thio-colchicine. La composition est administrée en une quantité qui est efficace pour inhiber l'angiogenèse mais qui, dans certains modes de réalisation, est insuffisante pour induire une cytotoxicité notable chez l'individu. Les procédés selon l'invention sont utilisables pour traiter les maladies associées à l'angiogenèse telles que la dégénérescence maculaire liée à l'âge, la rétinopathie diabétique, la polyarthrite rhumatoïde, le psoriasis et le cancer.
Desai Neil P.
Trieu Vuong
Abraxis Bioscience Llc
Smart & Biggar
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