A - Human Necessities – 61 – P
Patent
A - Human Necessities
61
P
A61P 7/02 (2006.01) A61K 31/19 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/60 (2006.01) A61K 31/715 (2006.01) A61K 38/02 (2006.01) A61K 38/49 (2006.01) A61K 45/06 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2361650
Provided is a method of treating thrombosis in mammals by administering therapeutically effective amounts of a combination of (i) a Factor Xa inhibitor, and (ii) a compound selected from the group consisting of aspirin, TPA, a GPIIb/IIIa antagonist, low molecular weight heparin and heparin, wherein the dose administered for at least one of (i) and (ii) is a subtherapeutic dose. Preferably, the combination of (i) and (ii) provides a synergistic effect.
L'invention concerne une méthode de traitement de la thrombose chez des mammifères consistant à administrer des quantités thérapeutiquement efficaces d'une combinaison (i) d'un inhibiteur du facteur Xa et (ii) d'un composé choisi dans le groupe constitué d'aspirine, de TPA, d'un antagoniste de GPIIb/IIIa, d'héparine à faible masse moléculaire et d'héparine. Concernant au moins un parmi (i) et (ii), la dose administrée est une dose subthérapeutique. De préférence, la combinaison de (i) et de (ii) produit un effet synergique.
Wong Pancras C.
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
Dupont Pharmaceuticals Company
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