Engineering antibodies that bind irreversibly

Details Engineering antibodies that bind irreversibly Engineering antibodies that bind irreversibly

Category

C - Chemistry, Metallurgy

Subcategory

07

Subsubcategory

K

IPC codes

C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 16/44 (2006.01) C12N 1/20 (2006.01) C12N 15/74 (2006.01) C12N 15/79 (2006.01) C12N 15/85 (2006.01)

Type

Patent

Patent number

CA 2385888

Description

The present invention provides a mutant antibody comprising a reactive site not present in the wild-type of the antibody and a complementarity-determining region that specifically binds to a metal chelate, wherein the reactive site is in a position proximate to or within the complementarity-determining region.

La présente invention concerne un anticorps mutant comprenant un site de réaction non présent dans le type sauvage de l'anticorps et une zone de détermination de la complémentarité qui se lie de façon spécifique à un chélate métallique. Le site de réaction se trouve dans une position proche, ou à l'intérieur, de la zone de détermination de la complémentarité.

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