Cycloalkanecarboxamide derivative and method for producing same

Details Cycloalkanecarboxamide derivative and method for producing same Cycloalkanecarboxamide derivative and method for producing same

C - Chemistry, Metallurgy

07

C

C07C 271/24 (2006.01) A61P 19/10 (2006.01) A61P 43/00 (2006.01) C07C 269/06 (2006.01) C07D 295/10 (2006.01) C07D 307/68 (2006.01) A61K 31/27 (2006.01) A61K 31/341 (2006.01) A61K 31/5375 (2006.01)

Patent

CA 2635787

Disclosed is a novel cycloalkanecarboxamide derivative having a selective cathepsin K inhibitory activity. Also disclosed is a method for producing such a cycloalkanecarboxamide derivative. Specifically disclosed is a cycloalkanecarboxamide derivative represented by the general formula (I) below or a pharmaceutically acceptable salt thereof. (I) (In the formula, R1 and R2 respectively represent a (substituted) alkyl group, a (substituted) alkenyl group, a (substituted) alkynyl group, a (substituted) aromatic hydrocarbon group, a (substituted) heterocyclic group; ring A represents an alkylidene group having 5-7 carbon atoms; and B represents a formyl group or a hydroxymethyl group.)

L'invention concerne un nouveau dérivé de cycloalcanecarboxamide possédant une action inhibitrice sélective sur la cathepsine K. L'invention concerne également un procédé destiné à la production de ce dérivé de cycloalcanecarboxamide. L'invention concerne tout particulièrement un dérivé de cycloalcanecarboxamide représenté par la formule générale (I) ci-dessous ou un de ses sels de qualité pharmaceutique. (Dans la formule générale (I), R1 et R2 désignent chacun un groupe alkyle (substitué), un groupe alcényle (substitué), un groupe alcynyle (substitué), un groupe hydrocarbure aromatique (substitué), un groupe hétérocyclique (substitué), le cycle A désigne un groupe alkylidène comportant 5-7 atomes de carbone, et B désigne un groupe formyle ou un groupe hydroxyméthyle.)

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