Fluorogenic benzoxazoles

Details Fluorogenic benzoxazoles Fluorogenic benzoxazoles

C - Chemistry, Metallurgy

07

D

260/228, 260/309

C07D 263/54 (2006.01) C07D 263/57 (2006.01) C07D 263/58 (2006.01) C07D 277/62 (2006.01) C07D 277/66 (2006.01) C07D 277/68 (2006.01) C07D 413/04 (2006.01) C07D 417/02 (2006.01) C07F 9/653 (2006.01) C07H 19/00 (2006.01) C12Q 1/34 (2006.01)

Patent

CA 2017269

The invention relates to fluorogenic compounds of the formula (I) (see formula I) in which X is O or S, R is a radical which can be split off by enzymatically catalyzed hydrolysis; R1 is H, C1- to C4-alkyl or phenyl, which can be substituted by 1 to 3 -CH3; and A has a molecular structure which lengthens the mesomerism of the benzohetercyclic ring system, in particular includes aromatic or heteroaromatic and also substituted and optionally benzo-fused 6- and 5-membered ring systems which can also attack in the 2-position of the benzoheterocyclic radical via one or more multiple bonds, or an electron-withdrawing group, such as CN or CF3. for the detection of hydrolyzing enzymes and the use of the fluorogenic compounds.

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