Benzothiophene urea, benzofurane urea, and indole urea, and...

Details Benzothiophene urea, benzofurane urea, and indole urea, and... Benzothiophene urea, benzofurane urea, and indole urea, and...

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2494352

The invention relates to novel benzothiophene-, benzofuran- and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory. In a specific embodiment, the invention relates to a compound of the formula See Formula (I) in which R1 is 1-azabicyclo[2.2.2]oct-3-yl, R2 is hydrogen or C1-C6-alkyl, R3 is hydrogen, etc., R4 is hydrogen, etc., R5 is hydrogen or C1-C6-alkyl, or R4 and R5 together with the nitrogen atom to which they are bonded are a 5- to 6-membered heterocycle, etc., R6 is (i) hydrogen, (ii) C1-C6-alkyl, etc., R5 and R6 together with the nitrogen atom to which they are bonded are a 3- to 10-membered heterocycle etc., A is oxygen, nitrogen or sulfur, X is oxygen or sulfur, the ring B is benzo or pyrido, etc., or a solvate, salt or solvate of the salt of this compound.

L'invention concerne de nouvelles urées de benzothiophène, de benzofuranne et d'indole ainsi que leur utilisation dans la production de médicaments destinés au traitement et/ou à la prophylaxie de maladies et à améliorer la perception, la capacité de concentration, la capacité d'apprentissage et/ou la capacité de mémorisation.

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