Process to manufacture simvastatin and intermediates

Details Process to manufacture simvastatin and intermediates Process to manufacture simvastatin and intermediates

C - Chemistry, Metallurgy

07

D

C07D 309/28 (2006.01) C07D 309/10 (2006.01) C07D 309/30 (2006.01)

Patent

CA 2240983

A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2'-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.

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