Novel antibody binding tcr and tirc7 and its use in therapy...

Details Novel antibody binding tcr and tirc7 and its use in therapy... Novel antibody binding tcr and tirc7 and its use in therapy...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 37/06 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2484182

Bispecific molecules characterized by having at least a first binding domain which binds T-cell immune response cDNA 7 (TIRC7) and a second binding domain which binds T cell receptor (TCR), in particular TCR beta or gamma chain; compositions comprising said bispecific molecules and their use for the diagnosis and the treatment of diseases related to a disorder of the immune response.

L'invention concerne des molécules bispécifiques caractérisées en ce qu'elles comportent au moins un premier domaine de liaison qui se lie à l'ADNc 7 à réponse immunitaire spécifique aux lymphocytes T (TIRC7) et un deuxième domaine de liaison qui se lie au récepteur des lymphocytes T (TCR), en particulier à la chaîne bêta ou gamma du TCR. L'invention concerne également des compositions contenant ces molécules bispécifiques et leur utilisation en diagnostic et traitement de maladies liées à un trouble de la réponse immunitaire.

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