C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) C07C 269/00 (2006.01) C07C 269/02 (2006.01)
Patent
CA 2433364
The present invention includes a method for carbamoylating an alcohol with sodium cyanate in the presence of methanesulfonic acid. The reaction can be conducted under anhydrous conditions. This method is suitable for carbamoylating a molecule including both an alcohol moiety and a basic moiety and/or a molecule including both an alcohol moiety and a sulfenyl moiety, such as the sulfenyl alcohol precursor of the antiviral agent Capravirine.
La présente invention concerne une méthode de carbamoylation d'un alcool avec du cyanate de sodium en présence d'acide méthanesulfonique. Ladite réaction peut être effectuée dans des conditions anhydres. Ladite méthode est conçue pour permettre la carbamoylation d'une molécule comprenant à la fois une fraction alcool et une fraction basique et/ou une molécule comprenant à la fois un groupe alcool et un groupe sulfényle, tel que l'alcool sulfényle précurseur de l'antiviral Capravirine.
Sim & Mcburney
Warner-Lambert Company Llc
LandOfFree
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